Ontology highlight
ABSTRACT:
SUBMITTER: Trindade BC
PROVIDER: S-EPMC8570345 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Trindade Bruno C BC Ceglia Simona S Berthelette Alyssa A Raso Fiona F Howley Kelsey K Muppidi Jagan R JR Reboldi Andrea A
Immunity 20211001 10
Diets high in cholesterol alter intestinal immunity. Here, we examined how the cholesterol metabolite 25-hydroxycholesterol (25-HC) impacts the intestinal B cell response. Mice lacking cholesterol 25-hydroxylase (CH25H), the enzyme generating 25-HC, had higher frequencies of immunoglobulin A (IgA)-secreting antigen-specific B cells upon immunization or infection. 25-HC did not affect class-switch recombination but rather restrained plasma cell (PC) differentiation. 25-HC was produced by follicul ...[more]