Factors affecting brain structure in smoking-related diseases: Chronic Obstructive Pulmonary Disease (COPD) and coronary artery disease.

ABSTRACT:

Background

Changes in brain structure and cognitive decline occur in Chronic Obstructive Pulmonary Disease (COPD). They also occur with smoking and coronary artery disease (CAD), but it is unclear whether a common mechanism is responsible.

Methods

Brain MRI markers of brain structure were tested for association with disease markers in other organs. Where possible, principal component analysis (PCA) was used to group markers within organ systems into composite markers. Univariate relationships between brain structure and the disease markers were explored using hierarchical regression and then entered into multivariable regression models.

Results

100 participants were studied (53 COPD, 47 CAD). PCA identified two brain components: brain tissue volumes and white matter m

SUBMITTER: Spilling CA 

PROVIDER: S-EPMC8570465 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature