Necrosis-induced apoptosis promotes regeneration in Drosophila wing imaginal discs.

ABSTRACT: Regeneration is a complex process that requires a coordinated genetic response to tissue loss. Signals from dying cells are crucial to this process and are best understood in the context of regeneration following programmed cell death, like apoptosis. Conversely, regeneration following unregulated forms of death, such as necrosis, have yet to be fully explored. Here, we have developed a method to investigate regeneration following necrosis using the Drosophila wing imaginal disc. We show that necrosis stimulates regeneration at an equivalent level to that of apoptosis-mediated cell death and activates a similar response at the wound edge involving localized JNK signaling. Unexpectedly, however, necrosis also results in significant apoptosis far from the site of ablation, which we have term

SUBMITTER: Klemm J 

PROVIDER: S-EPMC8570793 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature