Association and predictive value of biomarkers with severe outcomes in hospitalized patients with SARS-CoV-2 infection.

ABSTRACT: This study analyzed the levels at admission of biomarkers for their association with and ability to predict risk of severe outcomes, including admission to the ICU, need for invasive mechanical ventilation (IMV), need for vasopressor use (VU), and in-hospital mortality (IHM) in 700 patients hospitalized with COVID-19. Biomarker data split by outcomes was compared using Mann-Whitney U tests; frequencies of biomarker values were compared using Chi-square tests and multivariable logistic regression analysis was performed to look at the impact of biomarkers by outcome. Patients that suffered IHM were more likely to have reduced platelet numbers and high blood urea nitrogen (BUN) levels among patients admitted to the ICU. Risk factors for mortality were related to hyper-coagulability (low plate

SUBMITTER: Fernandez-Botran R 

PROVIDER: S-EPMC8570937 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature