Ontology highlight
ABSTRACT:
SUBMITTER: Qi L
PROVIDER: S-EPMC8571029 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Qi Le L Martin-Sandoval Misty S MS Merchant Salma S Gu Wen W Eckhardt Matthias M Mathews Thomas P TP Zhao Zhiyu Z Agathocleous Michalis M Morrison Sean J SJ
Cell stem cell 20210826 11
The electron transport chain promotes aspartate synthesis, which is required for cancer cell proliferation. However, it is unclear whether aspartate is limiting in normal stem cells. We found that mouse hematopoietic stem cells (HSCs) depend entirely on cell-autonomous aspartate synthesis, which increases upon HSC activation. Overexpression of the glutamate/aspartate transporter, Glast, or deletion of glutamic-oxaloacetic transaminase 1 (Got1) each increased aspartate levels in HSCs/progenitor c ...[more]