Transcriptomic heterogeneity of antibody mediated rejection after heart transplant with or without donor specific antibodies.

ABSTRACT:

Background

Antibody mediated rejection (AMR) is an increasingly studied cause of graft failure after heart transplantation. AMR diagnosis previously required the detection of circulating donor specific antibodies (DSA); however, the most recent criteria only require pathological findings. This classification defined a subset of patients with AMR, yet without known antibodies. Here, we sought to evaluate differences in the transcriptome profile associated with different types of AMR.

Methods

RNA sequencing was used on endomyocardial biopsies to analyze and compare transcriptomic profiles associated with different subtypes of AMR defined by immunopathological and histopathological findings, as well as the presence or absence of DSA. Gene expression profiles were characterized

SUBMITTER: Mantell BS 

PROVIDER: S-EPMC8571048 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature