High-fat and high-sodium diet induces metabolic dysfunction in the absence of obesity.

ABSTRACT:

Objective

Excess dietary fat and sodium (NaCl) are both associated with obesity and metabolic dysfunction. In mice, high NaCl has been shown to block high-fat (HF) diet-induced weight gain. Here, the impact of an HF/NaCl diet on metabolic function in the absence of obesity was investigated.

Methods

Wild-type mice were administered chow, NaCl (4%), HF, and HF/NaCl diets. Metabolic analysis was performed by measuring fasted blood glucose and insulin levels and by glucose tolerance test and insulin tolerance test.

Results

After 10 weeks on diets, male and female mice on the HF diet gained weight, and HF/NaCl mice had significantly reduced weight gain similar to chow-fed mice. In the absence of obesity, HF/NaCl mice had significantly elevated fasting blood glucose and imp

SUBMITTER: Frieler RA 

PROVIDER: S-EPMC8571049 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature