Donor derived cell free DNA% is elevated with pathogens that are risk factors for acute and chronic lung allograft injury.

ABSTRACT:

Background

Acute and chronic forms of lung allograft injury are associated with specific respiratory pathogens. Donor-derived cell free DNA (ddcfDNA) has been shown to be elevated with acute lung allograft injury and predictive of long-term outcomes. We examined the %ddcfDNA values at times of microbial isolation from bronchoalveolar lavage (BAL).

Methods

Two hundred and six BAL samples from 51 Lung Transplant Recipients (LTRs) with concurrently available plasma %ddcfDNA were analyzed along with microbiology and histopathology. Microbial species were grouped into bacterial, fungal, and viral and "higher risk" and "lower risk" cohorts based on historical association with downstream allograft dysfunction. Analyses were performed to determine pathogen category association with

SUBMITTER: Bazemore K 

PROVIDER: S-EPMC8571060 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature