B cells and food allergy.

ABSTRACT:

Purpose of review

B cells are known in food allergy pathogenesis for their production of IgE but their roles in the development of tolerance to foods are not well understood. Further understanding of B-cell biology in the context of food allergy is essential for the creation of effective prevention strategies and therapies.

Recent findings

The majority of allergen-specific IgE in humans appears to arise from antigen-experienced B cells that have already undergone class switch recombination to other antibody isotypes, such as IgG1, and can also be produced by cells class switching to IgE locally in the gastrointestinal tract. Allergen-specific IgG4 can have protective effects in individuals and is associated with tolerance. Regulatory B cells, which can produce allergen-speci

SUBMITTER: Udemgba C 

PROVIDER: S-EPMC8571066 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature