SPLUNC1: a novel marker of cystic fibrosis exacerbations.

ABSTRACT:

Background

Acute pulmonary exacerbations (AE) are episodes of clinical worsening in cystic fibrosis (CF), often precipitated by infection. Timely detection is critical to minimise morbidity and lung function declines associated with acute inflammation during AE. Based on our previous observations that airway protein short palate lung nasal epithelium clone 1 (SPLUNC1) is regulated by inflammatory signals, we investigated the use of SPLUNC1 fluctuations to diagnose and predict AE in CF.

Methods

We enrolled CF participants from two independent cohorts to measure AE markers of inflammation in sputum and recorded clinical outcomes for a 1-year follow-up period.

Results

SPLUNC1 levels were high in healthy controls (n=9, 10.7 μg·mL^-1), and significantly decreased

SUBMITTER: Khanal S 

PROVIDER: S-EPMC8571118 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature