⁶⁸Ga-PSMA-PET screening and transponder-guided salvage radiotherapy to the prostate bed alone for biochemical recurrence following prostatectomy: interim outcomes of a phase II trial.

ABSTRACT:

Purpose

To evaluate outcomes for men with biochemically recurrent prostate cancer who were selected for transponder-guided salvage radiotherapy (SRT) to the prostate bed alone by ⁶⁸Ga-labelled prostate-specific membrane antigen positron emission tomography (⁶⁸Ga-PSMA-PET).

Methods

This is a single-arm, prospective study of men with a prostate-specific antigen (PSA) level rising to 0.1-2.5 ng/mL following radical prostatectomy. Patients were staged with ⁶⁸Ga-PSMA-PET and those with a negative finding, or a positive finding localised to the prostate bed, continued to SRT only to the prostate bed alone with real-time target-tracking using electromagnetic transponders. The primary endpoint was freedom from biochemical relapse (FFBR, PSA > 0.2 ng/

SUBMITTER: Bowden P 

PROVIDER: S-EPMC8571130 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature