Association between serum retinol and overall and cause-specific mortality in a 30-year prospective cohort study.

ABSTRACT: How retinol as a clinical indicator of vitamin A status is related to long-term mortality is unknown. Here we report the results of a prospective analysis examining associations between serum retinol and risk of overall and cause-specific mortality. During a 30-year cohort follow-up, 23,797 deaths were identified among 29,104 men. Participants with higher serum retinol experienced significantly lower overall, CVD, heart disease, and respiratory disease mortality compared to men with the lowest retinol concentrations, reflecting 17-32% lower mortality risk (P_trend < 0.0001). The retinol-overall mortality association is similar across subgroups of smoking intensity, alcohol consumption, body mass index, trial supplementation, serum alpha-tocopherol and beta-carotene concentrations

SUBMITTER: Huang J 

PROVIDER: S-EPMC8571275 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature