Genomic landscape of metastatic lung adenocarcinomas from large-scale clinical sequencing.

ABSTRACT:

Background

Metastases are responsible for over 70% of deaths from lung adenocarcinomas. Previous large-scale studies of LUAD mainly focused on primary diseases. We aimed to comprehensively analyze the genomic landscape of metastatic LUADs and elucidate its clinical implications in the context of precision medicine.

Methods

We performed retrospective analyses on targeted sequencing data of 3,743 primary tumors and 934 metastases from 4,480 patients with lung adenocarcinomas, and PD-L1 immunohistochemical data of 1,336 primary tumors and 252 metastases from 1,588 LUAD patients.

Results

Metastases generally manifested significantly higher mutational burdens and chromosomal instability than primary lung adenocarcinomas. Clinically actionable alterations, including ALK mut

SUBMITTER: Li D 

PROVIDER: S-EPMC8571538 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature