The association of interferon-alpha with development of collateral circulation after artery occlusion.

ABSTRACT:

Background

Previous studies have demonstrated that interferon (IFN) signaling is enhanced in patients with poor collateral circulation (CC). However, the role and mechanisms of IFN-alpha in the development of CC remain unknown.

Methods

We studied the serum levels of IFN-alpha and coronary CC in a case-control study using logistics regression, including 114 coronary chronic total occlusion (CTO) patients with good coronary CC and 94 CTO patients with poor coronary CC. Restricted cubic splines was used to flexibly model the association of the levels of IFN-alpha with the incidence of good CC perfusion restoration after systemic treatment with IFN-alpha was assessed in a mice hind-limb ischemia model.

Results

Compared with the first IFN-alpha tertile, the risk of poor CC

SUBMITTER: Xing Z 

PROVIDER: S-EPMC8571556 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature