Venom proteomic analysis of medically important Nigerian viper Echis ocellatus and Bitis arietans snake species.

ABSTRACT: Snakebite envenoming remains a neglected tropical disease which poses severe health hazard, especially for the rural inhabitants in Africa. In Nigeria, vipers are responsible for the highest number of deaths. Hydrophilic interaction liquid chromatography coupled with LC-MS/MS was used to analyze the crude venoms of Echis ocellatus (Carpet viper) and Bitis arietans (Puff adder) in order to understand their venom proteomic identities. Results obtained revealed that gel-free proteomic analysis of the crude venoms led to the identification of 85 and 79 proteins, respectively. Seventy-eight (78) proteins were common between the two snake species with a 91.8% similarity score. The identified proteins belong to 18 protein families in E. ocellatus and 14 protein families in

SUBMITTER: Dingwoke EJ 

PROVIDER: S-EPMC8571701 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature