Molecular Spectra and Frequency Patterns of Somatic Mutations in Arab Women with Breast Cancer.

ABSTRACT:

Background

The role of somatic mutations in breast cancer prognosis and management continues to be recognized. However, data on the molecular profiles of Arab women are limited.

Materials and methods

This was a cross-sectional study based on medical chart review of all Arab women diagnosed with breast cancer at a single institution between 2010 and 2018 who underwent next-generation sequencing with Ampliseq 46-Gene or 50-Gene.

Results

A total of 78 Arab women were identified, with a median age at diagnosis of 52.3 years (range: 37-82 years; 38.5% ≤50 years). The majority of patients had stage III or IV disease (74.4%). Next-generation sequencing revealed the following somatic mutation rates: TP53, 23.1%; ATM, 2.6%; IDH1, 2.6%; IDH2, 3.8%; PTEN, 7.7%; PIK3CA, 15.4%; AP

SUBMITTER: Al-Shamsi HO 

PROVIDER: S-EPMC8571745 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature