Enhanced antibiotic prophylaxis and infection-related complications following prostate biopsy.

ABSTRACT:

Purpose

Sepsis after prostate biopsy is a costly and potentially lethal complication. We sought to assess whether enhanced antibiotic prophylaxis regimens combining oral and parenteral antibiotics may decrease the risk of post-biopsy urinary tract infection and sepsis compared to regimens with only oral antibiotics.

Methods

We identified men with commercial insurance who underwent prostate biopsy (2009-2015) with prophylactic antibiotic coverage. Our primary exposure of interest was antibiotic regimen: enhanced, oral-only, and parenteral-only. Post-biopsy outcomes of interest included urinary tract infections and sepsis/bacteremia after prostate biopsy. We used bivariate testing to assess associations between outcomes, exposures, and other covariates of interest. Multivariab

SUBMITTER: Steinberg RS 

PROVIDER: S-EPMC8571806 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature