Bovine milk somatic cell transcriptomic response to Staphylococcus aureus is dependent on strain genotype.

ABSTRACT:

Background

Mastitis is an economically important disease of dairy cows with Staphylococcus aureus a major cause worldwide. Challenge of Holstein-Friesian cows demonstrated that S. aureus strain MOK124, which belongs to Clonal Complex (CC)151, caused clinical mastitis, while strain MOK023, belonging to CC97, caused mild or subclinical mastitis. The aim of this study was to elucidate the molecular mechanisms of the host immune response utilising a transcriptomic approach. Milk somatic cells were collected from cows infected with either S. aureus MOK023 or MOK124 at 0, 24, 48, 72 and 168 h post-infection (hpi) and analysed for differentially expressed (DE) genes in response to each strain.

Results

In response to MOK023, 1278, 2278, 1986 and 1750 DE genes were found at 24, 48, 7

SUBMITTER: Niedziela DA 

PROVIDER: S-EPMC8571842 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature