Mask, the Drosophila ankyrin repeat and KH domain-containing protein, affects microtubule stability.

ABSTRACT: Proper regulation of microtubule (MT) stability and dynamics is vital for essential cellular processes, including axonal transportation and synaptic growth and remodeling in neurons. In the present study, we demonstrate that the Drosophila ankyrin repeat and KH domain-containing protein Mask negatively affects MT stability in both larval muscles and motor neurons. In larval muscles, loss-of-function of mask increases MT polymer length, and in motor neurons, loss of mask function results in overexpansion of the presynaptic terminal at the larval neuromuscular junctions (NMJs). mask genetically interacts with stathmin (stai), a neuronal modulator of MT stability, in the regulation of axon transportation and synaptic terminal stability. Our structure-function analysis of Mask revealed that it

SUBMITTER: Martinez D 

PROVIDER: S-EPMC8572007 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature