Lipid peroxidation as a hallmark of severity in COVID-19 patients.

ABSTRACT:

Background

Oxidative stress may be a key player in COVID-19 pathogenesis due to its significant role in response to infections. A defective redox balance has been related to viral pathogenesis developing a massive induction of cell death provoked by oxidative stress. The aim of this study is to perform a complete oxidative stress profile evaluation regarding antioxidant enzymes, total antioxidant capacity and oxidative cell damage in order to characterize its role in diagnosis and severity of this disease.

Methods

Blood samples were obtained from 108 COVID-19 patients and 28 controls and metabolites representative of oxidative stress were assessed. The association between lipid peroxidation and 28-day intubation/death risk was evaluated by multivariable regression analysis.

SUBMITTER: Martin-Fernandez M 

PROVIDER: S-EPMC8572041 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature