Laminar distribution and arbor density of two functional classes of thalamic inputs to primary visual cortex.

ABSTRACT: Motion/direction-sensitive and location-sensitive neurons are the two major functional types in mouse visual thalamus that project to the primary visual cortex (V1). It is under debate whether motion/direction-sensitive inputs preferentially target the superficial layers in V1, as opposed to the location-sensitive inputs, which preferentially target the middle layers. Here, by using calcium imaging to measure the activity of motion/direction-sensitive and location-sensitive axons in V1, we find evidence against these cell-type-specific laminar biases at the population level. Furthermore, using an approach to reconstruct axon arbors with identified in vivo response types, we show that, at the single-axon level, the motion/direction-sensitive axons project more densely to the middle layers t

SUBMITTER: Zhuang J 

PROVIDER: S-EPMC8572142 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature