Developmentally upregulated transcriptional elongation factor a like 3 suppresses axon regeneration after optic nerve injury.

ABSTRACT: Projection neurons of the mammalian central nervous system (CNS) do not spontaneously regenerate axons which have been damaged by an injury or disease, often leaving patients with permanent disabilities that affect motor, cognitive, or sensory functions. Although several molecular targets which promote some extent of axon regeneration in animal models have been identified, the resulting recovery is very limited, and the molecular mechanisms underlying the axonal regenerative failure in the CNS are still poorly understood. One of the most studied targets for axon regeneration in the CNS is the mTOR pathway. A number of developmentally regulated genes also have been found to play a role in CNS axon regeneration. Here, we found that Transcriptional Elongation Factor A Like 3 (Tceal3), belongi

SUBMITTER: Lukomska A 

PROVIDER: S-EPMC8572158 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature