A metabolome and microbiome wide association study of healthy eating index points to the mechanisms linking dietary pattern and metabolic status.

ABSTRACT:

Background

Healthy eating index (HEI), a measure of diet quality, associates with metabolic health outcomes; however, the molecular basis is unclear. We conducted a multi-omic study to examine whether HEI associates with the circulatory and gut metabolome and investigated the gut microbiome-HEI interaction on circulating and gut metabolites.

Methods

Through a cross-sectional study, we evaluated diet quality in healthy individuals [the ABO Glycoproteomics in Platelets and Endothelial Cells (ABO) Study, n = 73], metabolites (measured at Metabolon Inc.) in plasma (n = 800) and gut (n = 767) and the gut microbiome at enterotype and microbial taxa (n = 296) levels. Pathway analysis was conducted using Metaboanalyst 4.0. We performed multi-variable linear regression to explore bot

SUBMITTER: Bagheri M 

PROVIDER: S-EPMC8572162 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature