Tsukushi and TSKU genotype in obesity and related metabolic disorders.

ABSTRACT:

Purpose

Whether Tsukushi (TSK) can protect against high-fat diet (HFD)-induced obesity and improve glucose metabolism remains controversial. Serum levels of TSK in the population have not been reported until now. We assessed the association among TSK level, TSKU genotype, and metabolic traits in humans.

Methods

Associations between serum TSK levels and metabolic traits were assessed in 144 Han Chinese individuals. Loci in the TSKU gene region were further genotyped in 11,022 individuals. The association between the loci and serum TSK level was evaluated using the additive genetic model. The association between the loci and their metabolic traits in humans were also verified.

Results

Lower TSK levels were observed in obese subjects than in control subjects (median and

SUBMITTER: Li Y 

PROVIDER: S-EPMC8572186 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature