Urinary complement proteins and risk of end-stage renal disease: quantitative urinary proteomics in patients with type 2 diabetes and biopsy-proven diabetic nephropathy.

ABSTRACT:

Purpose

To investigate the association between urinary complement proteins and renal outcome in biopsy-proven diabetic nephropathy (DN).

Methods

Untargeted proteomic and Kyoto Encyclopedia of Genes and Genomes (KEGG) functional analyses and targeted proteomic analysis using parallel reaction-monitoring (PRM)-mass spectrometry was performed to determine the abundance of urinary complement proteins in healthy controls, type 2 diabetes mellitus (T2DM) patients, and patients with T2DM and biopsy-proven DN. The abundance of each urinary complement protein was individually included in Cox proportional hazards models for predicting progression to end-stage renal disease (ESRD).

Results

Untargeted proteomic and functional analysis using the KEGG showed that differentially exp

SUBMITTER: Zhao L 

PROVIDER: S-EPMC8572220 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature