Low-Dose Interleukin-2 as an Alternative Therapy for Refractory Lupus Nephritis.

ABSTRACT:

Introduction

Low-dose interleukin-2 (IL-2) selectively restores disturbances of regulatory T cells (Treg) and conventional T cells, resulting in the induction of remission in patients with systemic lupus erythematosus. However, to date no research has been carried out on the efficacy of low-dose IL-2 in the treatment of refractory lupus nephritis (LN). The aim of the study reported here was to investigate the renal response to low-dose IL-2 in patients with refractory LN.

Methods

The study population comprised ten patients with refractory LN who failed to achieve complete response or who had relapsed while being treated with at least two conventional immunosuppressive agents. One treatment cycle consisted of IL-2 at a dose of 1 million IU administered subcutaneously every ot

SUBMITTER: Zhang X 

PROVIDER: S-EPMC8572262 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature