Interaction between Genetic Risk Scores for reduced pulmonary function and smoking, asthma and endotoxin.

ABSTRACT:

Rationale

Genome-wide association studies (GWASs) have identified numerous loci associated with lower pulmonary function. Pulmonary function is strongly related to smoking and has also been associated with asthma and dust endotoxin. At the individual SNP level, genome-wide analyses of pulmonary function have not identified appreciable evidence for gene by environment interactions. Genetic Risk Scores (GRSs) may enhance power to identify gene-environment interactions, but studies are few.

Methods

We analysed 2844 individuals of European ancestry with 1000 Genomes imputed GWAS data from a case-control study of adult asthma nested within a US agricultural cohort. Pulmonary function traits were FEV₁, FVC and FEV₁/FVC. Using data from a recent large meta-ana

SUBMITTER: Sikdar S 

PROVIDER: S-EPMC8572320 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature