Serum non-esterified fatty acid levels and hip fracture risk: The Cardiovascular Health Study.

ABSTRACT: Among elderly participants from the Cardiovascular Health Study, we found that non-esterified trans fatty acid levels had a significant prospective association with hip fracture risk. Other non-esterified fatty acid classes were not associated with hip fracture risk.

Introduction

Serum non-esterified fatty acids (NEFAs) are bioactive metabolic intermediates that can be taken up by bone tissue. Their associations with hip fracture risk have not been previously examined.

Methods

Thirty-five individual NEFAs in five classes (saturated [SFA], mono-un-saturated [MUFA], poly-unsaturated n-6 and n-3 [PUFA], and trans-FA) were measured in Cardiovascular Health Study participants (n = 2139, mean age 77.8 years) without known diabetes. The multivariable associations of NEFA levels with

SUBMITTER: Barzilay JI 

PROVIDER: S-EPMC8572549 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature