Exposure to fruit-flavoring during adolescence increases nicotine consumption and promotes dose escalation.

ABSTRACT: The rise of e-cigarette popularity has sparked interest in the role of palatable flavors on nicotine use. Despite growing evidence that sweet flavorants enhance nicotine reward, their influence on nicotine consumption has not been studied extensively. In addition, the impact that flavored nicotine use in adolescence could have on nicotine reward and dependence in adulthood remains unclear. This study examined the role of flavored nicotine access on nicotine preference and consumption longitudinally, from adolescence to adulthood. Male and female adolescent mice preferred a fruit-flavored nicotine solution over an unflavored nicotine solution. However, only adolescent female mice with access to flavored nicotine consumed higher doses. Furthermore, while adolescent male mice escalated consum

SUBMITTER: Patten T 

PROVIDER: S-EPMC8572580 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature