Microbiota regulates the turnover kinetics of gut macrophages in health and inflammation.

ABSTRACT: The gut immune system has evolved to co-exist in a mutually beneficial symbiotic relationship with its microflora. Here, using a germ-free fate-mapping mouse model, we provide clear insight into how the enteric commensals determine the kinetics of macrophage turnover. The microbiome density along the gastrointestinal tract defines the persistence of ontogenically diverse macrophages, with the highest numbers of the long-lived F4/80^hiTim4⁺ macrophage subset in the less densely colonized small intestine. Furthermore, the microbiome contributes to a tightly regulated monocyte-dependent replenishment of both long- and short-lived F4/80^hi macrophages under homeostatic and inflammatory conditions. In the latter situation, the commensals regulate rapid replenishme

SUBMITTER: Chen Q 

PROVIDER: S-EPMC8572849 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature