Beyond Vessel Diameters: Non-invasive Monitoring of Flow Patterns and Immune Cell Recruitment in Murine Abdominal Aortic Disorders by Multiparametric MRI.

ABSTRACT: The pathophysiology of the initiation and progression of abdominal aortic aneurysms (AAAs) and aortic dissections (AADs) is still unclear. However, there is strong evidence that monocytes and macrophages are of crucial importance in these processes. Here, we utilized a molecular imaging approach based on background-free ¹⁹F MRI and employed perfluorocarbon nanoemulsions (PFCs) for in situ ¹⁹F labeling of monocytes/macrophages to monitor vascular inflammation and AAA/AAD formation in angiotensin II (angII)-treated apolipoproteinE-deficient (apoE^-/-) mice. In parallel, we used conventional ¹H MRI for the characterization of aortic flow patterns and morphology. AngII (1 μg/kg/min) was infused into apoE^-/- mice via osmotic mi

SUBMITTER: Temme S 

PROVIDER: S-EPMC8572976 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature