Lipotoxic Proximal Tubular Injury: A Primary Event in Diabetic Kidney Disease.
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ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC8573085 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
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Lipotoxic Proximal Tubular Injury: A Primary Event in Diabetic Kidney Disease.
Wang Hua H Zhang Shu S Guo Jia J
Frontiers in medicine 20211025
The pathogenesis of diabetic nephropathy is a complex process that has a great relationship with lipotoxicity. Since the concept of "nephrotoxicity" was proposed, many studies have confirmed that lipotoxicity plays a significant role in the progression of diabetic nephropathy and causes various renal dysfunction. This review will make a brief summary of renal injury caused by lipotoxicity that occurs primarily and predominantly in renal tubules during diabetic progression, further leading to glo ...[more]
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