Association Between Plasma Amyloid-β and Neuropsychological Performance in Patients With Cognitive Decline.

ABSTRACT: Objective: To investigate the association between plasma amyloid-β (Aβ) levels and neuropsychological performance in patients with cognitive decline using a highly sensitive nano-biosensing platform. Methods: We prospectively recruited 44 patients with cognitive decline who underwent plasma Aβ analysis, amyloid positron emission tomography (PET) scanning, and detailed neuropsychological tests. Patients were classified into a normal control (NC, n = 25) or Alzheimer's disease (AD, n = 19) group based on amyloid PET positivity. Multiple linear regression was performed to determine whether plasma Aβ (Aβ₄₀, Aβ₄₂, and Aβ_42/40) levels were associated with neuropsychological test results. Results: The plasma levels of Aβ_42/4

SUBMITTER: Yun G 

PROVIDER: S-EPMC8573146 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature