Concordance of HIV transmission risk factors elucidated using viral diversification rate and phylogenetic clustering.

ABSTRACT:

Background and objectives

Although HIV sequence clustering is routinely used to identify subpopulations experiencing elevated transmission, it over-simplifies transmission dynamics and is sensitive to methodology. Complementarily, viral diversification rates can be used to approximate historical transmission rates. Here, we investigated the concordance and sensitivity of HIV transmission risk factors identified by phylogenetic clustering, viral diversification rate, changes in viral diversification rate and a combined approach.

Methodology

Viral sequences from 9848 people living with HIV in British Columbia, Canada, sampled between 1996 and February 2019, were used to infer phylogenetic trees, from which clusters were identified and viral diversification rates of each tip we

SUBMITTER: McLaughlin A 

PROVIDER: S-EPMC8573190 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature