Association between Paraoxonase-1 p.Q192R Polymorphism and Coronary Artery Disease susceptibility in the Colombian Population.

ABSTRACT:

Background

Paraoxonase-1 (PON1), a glycoprotein associated with serum high-density lipoprotein (HDL), has a central role in metabolizing lipid peroxides, exhibiting antiatherogenic properties. The polymorphism p.Q192R has been previously associated with coronary artery disease (CAD) susceptibility and clopidogrel response.

Purpose

We aimed at investigating the association of PON1 p.Q192R with CAD and clopidogrel response in Colombian population.

Patients and methods

The study was conducted among 163 patients diagnosed with CAD and treated with clopidogrel. The allele frequencies for the PON1 192Q and 192R alleles were determined in cases and Latin-American controls obtained from the public database gnomAD (n = 17,711). Response to clopidogrel was determined by assessi

SUBMITTER: Corredor-Orlandelli D 

PROVIDER: S-EPMC8573264 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature