Cellular Size, Gap Junctions, and Sodium Channel Properties Govern Developmental Changes in Cardiac Conduction.

ABSTRACT: Electrical conduction in cardiac ventricular tissue is regulated via sodium (Na⁺) channels and gap junctions (GJs). We and others have recently shown that Na⁺channels preferentially localize at the site of cell-cell junctions, the intercalated disc (ID), in adult cardiac tissue, facilitating coupling via the formation of intercellular Na⁺nanodomains, also termed ephaptic coupling (EpC). Several properties governing EpC vary with age, including Na⁺channel and GJ expression and distribution and cell size. Prior work has shown that neonatal cardiomyocytes have immature IDs with Na⁺channels and GJs diffusively distributed throughout the sarcolemma, while adult cells have mature IDs with preferentially localized Na⁺channels and G

SUBMITTER: Nowak MB 

PROVIDER: S-EPMC8573326 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature