The dUTPase of caprine arthritis-encephalitis virus negatively regulates interferon signaling pathway.

ABSTRACT:

Background

Deoxyuracil triphosphate nucleotide (dUTP) pyrophosphatase (dUTPase, DU) is an enzyme of caprine arthritis-encephalitis virus (CAEV) that minimizes incorporation of dUTP into the DNA. Caprine arthritis-encephalitis virus relies partly on its ability to escape from innate immunity to cause persistent infections. Interferon β (IFN-β) is an important marker for evaluating the innate immune system, and it has a broad spectrum of antiviral activity.

Aims

This study was conducted to investigate the details of the IFN-β response to CAEV infection.

Methods

The expression of IFN-β and the proliferation of Sendai virus (SeV) and vesicular stomatitis virus (VSV) were determined by real-time quantitative polymerase chain reaction (qPCR). The effect of DU on the IFN sig

SUBMITTER: Shi J 

PROVIDER: S-EPMC8573393 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature