Protein Kinase C-Dependent Effects of Neurosteroids on Synaptic GABA_A Receptor Inhibition Require the δ-Subunit.

ABSTRACT: The dorsal motor nucleus of the vagus (DMV) contains preganglionic motor neurons important for interpreting sensory input from the periphery, integrating that information, and coding the appropriate parasympathetic (vagal) output to target organs. Despite the critical role of hormonal regulation of vagal motor output, few studies examine the role of neurosteroids in the regulation of the DMV. Of the few examinations, no studies have investigated the potential impact of allopregnanolone (Allo), a neuroactive progesterone-derivative, in the regulation of neurotransmission on the DMV. Since DMV neuronal function is tightly regulated by GABA_A receptor activity and Allo is an endogenous GABA_A receptor ligand, the present study used in vitro whole cell patch clamp to

SUBMITTER: Littlejohn EL 

PROVIDER: S-EPMC8573421 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature