Schisandrin B regulates macrophage polarization and alleviates liver fibrosis via activation of PPARγ.

ABSTRACT:

Background

Schisandrin B (Sch B), the main ingredient of Schisandra chinensis, displays many bioactivities. This study aimed to identify the drug target of Sch B against liver fibrosis and describe the related molecular mechanisms.

Methods

The effects of Sch B on liver fibrosis and macrophage polarization was investigated in vivo and in vitro. Furthermore, we analyzed the regulatory effect of Sch B on peroxisome proliferator-activated receptor gamma (PPARγ).

Results

Our data showed that Sch B dramatically alleviated liver inflammation and fibrosis and inhibited macrophage activation via PPARγ. Sch B binds with PPARγ by molecular docking. Immunofluorescence double staining showed that PPARγ was mainly expressed in macrophages rather than hepatic st

SUBMITTER: Chen Q 

PROVIDER: S-EPMC8573433 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature