Circular RNAs as potential regulators in bone remodeling: a narrative review.

ABSTRACT:

Objective

In this review, we focus on the recent progress of circular ribonucleic acids (circRNAs)-related molecular mechanisms in the processes of osteogenesis and osteoclastogenesis, and explore their roles in the development of bone-remodeling disorders.

Background

The well-coupled bone-formation and bone-resorption processes are vital in bone remodeling. Once the balance is disrupted, bone-remodeling disorders (e.g., osteoporosis and osteopetrosis) occur, severely affecting patients' quality of life. CircRNAs, the newly discovered members of the non-coding RNA family, have been reported to act as key checkpoints of various signaling pathways that influence osteoblasts and osteoclasts functions, thus regulating the physiological and pathological processes of bone homeosta

SUBMITTER: Pan X 

PROVIDER: S-EPMC8573438 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature