Mechanisms and pharmacological applications of ferroptosis: a narrative review.

ABSTRACT:

Objective

We aimed at comprehensively analyzing ferroptosis regulation and its potential role in the treatment of associated diseases.

Background

Ferroptosis is a recently discovered form of cell death that involves small molecule-induced oxidative cell death. This process is usually accompanied by large amounts of iron accumulation and lipid peroxidation. Ferroptosis inducers directly or indirectly affect glutathione peroxidase (GPXs) through different pathways. Disturbances in GPXs result in suppressed cellular antioxidant capacities, accumulation of lipid reactive oxygen species (ROS) and oxidative cell death. It has been reported that ferroptosis is closely associated with the pathophysiological processes of many diseases, including tumors, nervous system diseases, ische

SUBMITTER: Zhang JJ 

PROVIDER: S-EPMC8573439 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature