The clinical value of valve metagenomic next-generation sequencing when applied to the etiological diagnosis of infective endocarditis.

ABSTRACT:

Background

Metagenomic next-generation sequencing (mNGS) is widely applied in the etiological diagnosis of infectious diseases. However, the clinical practice of mNGS in infective endocarditis (IE) is relatively less studied. This research aimed to assess the etiological diagnostic value of valve mNGS in IE.

Methods

We retrospectively analyzed 49 IE patients who underwent cardiac valve surgery in Zhongshan Hospital, Fudan University, Shanghai from 1 June 2018 to 30 November 2020. Among these IE patients, 28 were culture positive and 21 were culture negative. The culture results of the culture-positive IE patients were set as gold standard to assess the sensitivity and specificity of valve mNGS in the etiological diagnosis of IE. We studied the positive detection rate of path

SUBMITTER: Cai S 

PROVIDER: S-EPMC8573444 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature