Bioinformatics analysis of high frequency mutations in myelodysplastic syndrome-related patients.

ABSTRACT:

Background

Myelodysplastic syndrome (MDS) is a group of hematological malignancies that may progress to acute myeloid leukemia (AML). Bioinformatics-based analysis of high-frequency mutation genes in MDS-related patients is still relatively rare, so we conducted our research to explore whether high-frequency mutation genes in MDS-related patients can play a reference role in clinical guidance and prognosis.

Methods

Next generation sequencing (NGS) technology was used to detect 32 mutations in 64 MDS-related patients. We classified the patients' genes and analyzed them by Gene Ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, protein-protein interaction (PPI) analysis, and then calculated the gene survival curve of high-frequency mutations.

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SUBMITTER: Wu K 

PROVIDER: S-EPMC8573449 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature