Ontology highlight
ABSTRACT:
SUBMITTER: Bandyopadhyay AK
PROVIDER: S-EPMC8573455 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Bandyopadhyay Amal Kumar AK Ul Islam Rifat Nawaz RN Hazra Niladri N
Bioinformation 20201130 11
Salt-bridges (sb) play an important role in the folding and stability of proteins. This is deduced from the evaluation of net energy in the microenvironments (ME, residues that are 4 Å away from positive and negative partners of salt-bridge and interact with them). MEs act as a determinant of net-energy due to the intrinsic features in the sequence. The stability of extremophilic proteins is due to the presence of favorable residues at the ME without any unfavorable residues. We studied a datase ...[more]