Comprehensive analysis of prognostic value of lymph node classifications in esophageal squamous cell carcinoma: a large real-world multicenter study.

ABSTRACT:

Background

We aim to assess the prognostic ability of three common lymph node-based staging algorithms, namely, the number of positive lymph nodes (pN), the lymph node ratio (LNR), and log odds of positive lymph nodes (LODDS) in patients with esophageal squamous cell carcinoma (ESCC).

Methods

A total of 3902 ESCC patients treated at 10 Chinese institutions between 2003 and 2013 were included, along with 2465 patients from the Surveillance, Epidemiology, and End Results (SEER) database. The prognostic ability of the aforementioned algorithms was evaluated using time-dependent receiver operating characteristic (tdROC) curves, R ², Harrell's concordance index (C-index), and the likelihood ratio chi-square score. The primary outcomes included cancer-specific su

SUBMITTER: Wen J 

PROVIDER: S-EPMC8573486 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature