Effects of melatonin on sleep disturbances in multiple sclerosis: A randomized, controlled pilot study.

ABSTRACT:

Background

Sleep disturbances are commonly reported by people with multiple sclerosis (PwMS). However, optimal management of sleep disturbances is uncertain, and objective studies of sleep quality in PwMS are scarce.

Objectives

To determine the effect of exogenous melatonin on sleep quality and sleep disturbances in PwMS.

Methods

Thirty adult PwMS reporting sleep difficulties were recruited in a randomized, controlled, double-blind cross-over study. They took either melatonin or placebo for 2 weeks, and the opposite for the following 2 weeks. During weeks 2 and 4, an actigraph was used to capture mean total sleep time and sleep efficiency. Patient-reported outcomes (PROs) were collected at weeks 0, 2 and 4.

Results

Melatonin use significantly improved mean tota

SUBMITTER: Hsu WY 

PROVIDER: S-EPMC8573503 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature