Defining the structure of the NF-ĸB pathway in human immune cells using quantitative proteomic data.

ABSTRACT: The NF-ĸB transcription factor is a critical regulator of immune homeostasis and inflammatory responses and is a critical factor in the pathogenesis of inflammatory disease. The pathways to NF-ĸB activation are paradigms for signal-induced ubiquitination and proteasomal degradation, control of transcription factor function by subcellular localisation, and the control of gene transcription and physiological processes by signal transduction mechanisms. Despite the importance of NF-ĸB in disease, the NF-ĸB pathway remains unexploited for the treatment of inflammatory disease. Our understanding of NF-ĸB comes mostly from studies of transgenic mice and cell lines where components of the pathway have been deleted or over expressed. Recent advances in quantitative proteomics offer new opportuniti

SUBMITTER: Kok FO 

PROVIDER: S-EPMC8573605 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature