The Effect of Body Mass Index on Brain Volume and Cognitive Function in Relapsing-Remitting Multiple sclerosis: A CombiRx Secondary Analysis.

ABSTRACT:

Background

Multiple sclerosis (MS) is an autoimmune disease leading to physical, emotional and cognitive disability. High body mass index (BMI) may impact cognitive function and brain volume in MS. Yet, there is paucity of evidence addressing the impact of BMI on cognitive function and brain volume in MS.

Objectives

The purpose of this study was to examine the effects of BMI on normal appearing brain volume and cognitive function in patients with relapsing-remitting MS.

Methods

A secondary data analysis of the NIH CombiRx study was conducted. Multivariate regression and mixed model analyses were executed to analyze the effect of BMI on brain volume and cognitive function.

Results

The mean baseline age of the 768 participants was 38.2(SD = 9.4) years. 73% were f

SUBMITTER: Ben-Zacharia AB 

PROVIDER: S-EPMC8573693 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature