Projected 20- and 30-Year Outcomes for Pediatric Liver Transplant Recipients in the United States.

ABSTRACT:

Background

Observed long-term outcomes no longer reflect the survival trajectory facing pediatric liver transplant (LT) recipients today. We aimed to use national registry data and parametric models to project 20- and 30-year post-transplant outcomes for recently transplanted pediatric LT recipients.

Methods

We conducted a retrospective cohort study of 13,442 first-time pediatric (age <18) LT recipients using 1987 to 2018 Scientific Registry of Transplant Recipients data. We validated the proposed method (ie, to project long-term patient and graft survival using parametric survival models and short-term data) in 2 historic cohorts (1987-1996 and 1997-2006) and estimated long-term projections among patients transplanted between 2007 and 2018. Projections were stratified by ra

SUBMITTER: Bowring MG 

PROVIDER: S-EPMC8573715 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature