Development and preclinical evaluation of a patient-specific high energy x-ray phase sensitive breast tomosynthesis system.

ABSTRACT:

Background

This article reports the first x-ray phase sensitive breast tomosynthesis (PBT) system that is aimed for direct translation to clinical practice for the diagnosis of breast cancer.

Purpose

To report the preclinical evaluation and comparison of the newly built PBT system with a conventional digital breast tomosynthesis (DBT) system.

Methods and materials

The PBT system is developed based on a comprehensive inline phase contrast theoretical model. The system consists of a polyenergetic microfocus x-ray source and a flat panel detector mounted on an arm that is attached to a rotating gantry. It acquires nine projections over a 15° angular span in a stop-and-shoot manner. A dedicated phase retrieval algorithm is integrated with a filtered back-projection method

SUBMITTER: Ghani MU 

PROVIDER: S-EPMC8573724 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature